• Think MEAN:
  • Multiple
  • Early ages
  • Ancestry (eg. Adopted or Ashkenazi)
  • uNcommon types of cancer (pancreas, thyroid, brain, kidney, bladder, liver, lymphomas,etc)

Note: These lists do not include ALL possible ‘red flags’ that may indicate need for testing.​


  • Prior history of cancer, especially breast cancer, at a young age and/or bilateral.
  • Multiple family members, male or female, with breast or other cancers. 
  • First Degree relative with breast, ovarian, or other cancer at a young age. 
  • History of abnormal breast biopsy such as atypia or LCIS.
  • Diagnosis of triple negative breast cancer.
  • Known mutation in family member. 
  • Risk score >20% on risk assessment.
  • Ashkenazi Jewish Ancestry.


  • Less than age 50 with diagnosis of colon or rectal cancer.
  • Less than age 60 with specific tumor types related to Lynch Syndrome. 
  • Multiple types of cancer in individual or close relatives (uterine, ovarian, stomach, pancreas, kidney, etc)..
  • More than 10 polyps or history of inflammatory bowel or polyposis syndrome. 


  • Diagnosis of cancer with Gleason Score 7 or higher (high grade)

  • Metastatic prostate cancer. 

  • Family history of high grade or metastatic cancer..

  • Family members with Breast, Ovarian, Pancreas, Melanoma, or other cancers.

  • Known mutation in family member.

MELANOMA (skin cancer)

  • Family members, especially multiple members, with melanoma.
  • Atypical moles/dysplastic nevus syndrome.
  • Known FAMM (familial multiple mole and melanoma).
  • Excessive radiation or toxic chemical exposures.

GYN (ovarian/uterine)

  • Ovarian cancer at any age.
  • Family history of ovarian cancer.
  • Breast, Ovarian, Uterine, or other cancers related to syndromes.
  • Known cancer gene mutation in family, such as BRCA, Lynch, or others.


red flags